Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

An, Lijun; Ma, Jun; Yang, Xueyuan; Liang, Yue; Wang, Huimei; Tuerhong, Muhetaer; Lall, Namrita; Abudukeremu, Munira; Zhang, Yi; Lee, Dongho; Xu, Jing; Wu, Xiaohui; Guo, Yuanqiang

doi:10.1016/j.bioorg.2020.103758

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Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

An, Lijun;
Ma, Jun;
Yang, Xueyuan;
Liang, Yue;
Wang, Huimei;
... Lee, Dongho;
외 7명

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초록

Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

키워드

Homotriterpenoid; Anti-inflammation; Zebrafish model; Molecular docking; Casearia kurzii; CYTOTOXIC CLERODANE DITERPENOIDS; LEAVES; SYLVESTRIS; TRITERPENOIDS; DERIVATIVES; INHIBITOR; GLYCOSIDE; TWIGS; BARK

제목: Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

저자: An, Lijun; Ma, Jun; Yang, Xueyuan; Liang, Yue; Wang, Huimei; Tuerhong, Muhetaer; Lall, Namrita; Abudukeremu, Munira; Zhang, Yi; Lee, Dongho; Xu, Jing; Wu, Xiaohui; Guo, Yuanqiang

DOI: 10.1016/j.bioorg.2020.103758

발행일: 2020-05

유형: Article

저널명: Bioorganic Chemistry

권: 98