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Inhibitors of nitric oxide production from Artemisia princeps
- Li, D.;
- Han, X.H.;
- Hong, S.S.;
- Lee, C.;
- Lee, M.S.;
- ... Lee, D.;
- 외 2명
Citations
SCOPUS
7초록
The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC50 values of 19.5, 20.4 and 25.1 μM, respectively.
키워드
Artemisia princeps; Compositae; Nitric oxide production inhibitor; Sesquiterpene lactone; mass spectrometry; medicinal plant; mouse; nonhuman; nuclear Overhauser effect; proton nuclear magnetic resonance; thin layer chromatography; artecanin; canin; eupatilin; flavanoid; lipopolysaccharide; methanol; nitric oxide synthase inhibitor; sesquiterpene lactone; unclassified drug; animal cell; artemisia princeps; article; carbon nuclear magnetic resonance; drug isolation; drug mechanism; drug structure; drug synthesis; IC 50; macrophage
- 제목
- Inhibitors of nitric oxide production from Artemisia princeps
- 저자
- Li, D.; Han, X.H.; Hong, S.S.; Lee, C.; Lee, M.S.; Lee, D.; Lee, M.K.; Hwang, B.Y.
- 발행일
- 2010
- 유형
- Article
- 권
- 16
- 호
- 3
- 페이지
- 143 ~ 147