Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Kim, Jeong Geun; Yang, Eun Hae; Youn, Woo Sup; Choi, Ji Won; Ha, Deok-Chan; Ha, Jae Du

doi:10.1016/j.tetlet.2010.05.021

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Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Kim, Jeong Geun;
Yang, Eun Hae;
Youn, Woo Sup;
Choi, Ji Won;
Ha, Deok-Chan;
외 1명

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초록

A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 degrees C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions. (C) 2010 Elsevier Ltd. All rights reserved.

키워드

Microwave-assisted amination; 3-Bromo-2-chloropyridine; Aminoethanol; Pyrido[1,4]oxazine; ARYL CHLORIDES; BOND FORMATION; EFFICIENT; DESIGN; ANTAGONISTS; INHIBITORS; CATALYSTS; LIGANDS; POTENT

제목: Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

저자: Kim, Jeong Geun; Yang, Eun Hae; Youn, Woo Sup; Choi, Ji Won; Ha, Deok-Chan; Ha, Jae Du

DOI: 10.1016/j.tetlet.2010.05.021

발행일: 2010-07-28

유형: Article

저널명: Tetrahedron Letters

권: 51

호: 30

페이지: 3886 ~ 3889