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Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells
- Jang, Hari;
- Lee, Jin Woo;
- Lee, Chul;
- Jin, Qinghao;
- Choi, Jeong Yeon;
- ... Lee, Dongho;
- 외 5명
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27초록
A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 mu M.
키워드
Tussilago farfara; Asteraceae; Oplopane-type; sesquiterpenoid; Nitric oxide production inhibitor; OCCURRING TERPENE DERIVATIVES; FLOWER BUDS; CONSTITUENTS; EXTRACTION
- 제목
- Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells
- 저자
- Jang, Hari; Lee, Jin Woo; Lee, Chul; Jin, Qinghao; Choi, Jeong Yeon; Lee, Dongho; Han, Sang Bae; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- 발행일
- 2016-01
- 유형
- Article
- 권
- 39
- 호
- 1
- 페이지
- 127 ~ 132
- 언어
- ENG
- 출판사
- PHARMACEUTICAL SOC KOREA
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- E 1976-3786
P 0253-6269