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Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis
- Kim, Won Young;
- Won, Miae;
- Salimi, Abbas;
- Sharma, Amit;
- Lim, Jong Hyeon;
- ... Kim, Jong Seung;
- 외 3명
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Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
키워드
ANTIGEN
- 제목
- Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis
- 저자
- Kim, Won Young; Won, Miae; Salimi, Abbas; Sharma, Amit; Lim, Jong Hyeon; Kwon, Seung-Hae; Jeon, Joo-Yeong; Lee, Jin Yong; Kim, Jong Seung
- 발행일
- 2019-11-14
- 유형
- Article
- 권
- 55
- 호
- 88
- 페이지
- 13267 ~ 13270