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Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata
- Kwon, Jaeyoung;
- Nguyen Tuan Hiep;
- Kim, Dong-Woo;
- Hwang, Bang Yeon;
- Lee, Hak Ju;
- ... Lee, Dongho;
- 외 1명
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46초록
Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SYSY cells, with EC50 values of 0.7-16.6 mu M.
키워드
ISOPRENYLATED XANTHONES; PRENYLATED XANTHONES; PARKINSONS-DISEASE; OXIDATIVE STRESS; MODEL; CYTOTOXICITY; CONSTITUENTS; ANTIOXIDANT; FLAVONOIDS; COMPONENTS
- 제목
- Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata
- 저자
- Kwon, Jaeyoung; Nguyen Tuan Hiep; Kim, Dong-Woo; Hwang, Bang Yeon; Lee, Hak Ju; Mar, Woongchon; Lee, Dongho
- 발행일
- 2014-08
- 유형
- Article
- 권
- 77
- 호
- 8
- 페이지
- 1893 ~ 1901
- 언어
- ENG
- 출판사
- AMER CHEMICAL SOC
- 발행국가
- 미국
- 분량
- 9 페이지
- ISSN
- E 1520-6025
P 0163-3864