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Multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole DNA biosensor for label-free detection of genetically modified organisms by QCM and EIS
- Lien, Truong Thi Ngoc;
- Lam, Tran Dai;
- An, Vu Thi Hong;
- Hoang, Tran Vinh;
- Quang, Duong Tuan;
- ... Kim, Jong Seung;
- 외 3명
WEB OF SCIENCE
89SCOPUS
87초록
In this paper, we describe DNA electrochemical detection for genetically modified organism (GMO) based on multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole (PPy). DNA hybridization is studied by quartz crystal microbalance (QCM) and electrochemical impedance spectroscopy (EIS). An increase in DNA complementary target concentration results in a decrease in the faradic charge transfer resistance (R-ct) and signifying "signal-on" behavior of MWCNTs-PPy-DNA system. QCM and EIS data indicated that the electroanalytical MWCNTs-PPy films were highly sensitive (as low as 4 pM of target can be detected with QCM technique). In principle, this system can be suitable not only for DNA but also for protein biosensor construction. (C) 2009 Elsevier B.V. All rights reserved.
키워드
- 제목
- Multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole DNA biosensor for label-free detection of genetically modified organisms by QCM and EIS
- 저자
- Lien, Truong Thi Ngoc; Lam, Tran Dai; An, Vu Thi Hong; Hoang, Tran Vinh; Quang, Duong Tuan; Khieu, Dinh Quang; Tsukahara, Toshifumi; Lee, Young Hoon; Kim, Jong Seung
- 발행일
- 2010-01-15
- 유형
- Article
- 저널명
- Talanta
- 권
- 80
- 호
- 3
- 페이지
- 1164 ~ 1169