Impact of stent designs ofsecond-generation drug-elutingstents on long-term outcomes in coronary bifurcation lesions

초록

Objectives We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group,n= 514), platinum chromium everolimus-eluting stent (PtCr-EES group,n= 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group,n= 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group,n= 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group,p= .434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively,p= .554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (pfor interaction = .691). Conclusion There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.

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