Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Kim, Nahyun; Cho, Kyu-Won; Hong, Seong Su; Hwang, Bang Yeon; Chun, Taehoon; Lee, Dongho

doi:10.1016/j.bmcl.2014.12.007

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Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

Kim, Nahyun;
Cho, Kyu-Won;
Hong, Seong Su;
Hwang, Bang Yeon;
Chun, Taehoon;
... Lee, Dongho

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초록

Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

키워드

Dictamnus dasycarpus; Rutaceae; Glabretal-type triterpenoid; Antiproliferative effect; TIRUCALLANE TRITERPENOIDS; CONSTITUENTS; ALKALOIDS; ALBUS; APOTIRUCALLANE; CYCLOSPORINE; GLYCOSIDES; CELLS; ACIDS

제목: Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus

저자: Kim, Nahyun; Cho, Kyu-Won; Hong, Seong Su; Hwang, Bang Yeon; Chun, Taehoon; Lee, Dongho

DOI: 10.1016/j.bmcl.2014.12.007

발행일: 2015-02-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 25

호: 3

페이지: 621 ~ 625