Palladium-Catalyzed Decarboxylative Trifluoroethylation of Aryl Alkynyl Carboxylic Acids

Hwang, Jinil; Park, Kyungho; Choe, Juseok; Min, Hongkeun; Song, Kwang Ho; Lee, Sunwoo

doi:10.1021/jo5003032

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Palladium-Catalyzed Decarboxylative Trifluoroethylation of Aryl Alkynyl Carboxylic Acids

Hwang, Jinil;
Park, Kyungho;
Choe, Juseok;
Min, Hongkeun;
Song, Kwang Ho;
외 1명

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WEB OF SCIENCE

64

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SCOPUS

62

초록

A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(eta(3)-allyl)Cl](2)/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 degrees C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

키워드

TERMINAL ALKYNES; ELECTROPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; MEDIATED FLUORINATION; UNACTIVATED ALKENES; COUPLING REACTIONS; HALIDES; AMINOFLUORINATION; STRATEGY; CARBON

제목: Palladium-Catalyzed Decarboxylative Trifluoroethylation of Aryl Alkynyl Carboxylic Acids

저자: Hwang, Jinil; Park, Kyungho; Choe, Juseok; Min, Hongkeun; Song, Kwang Ho; Lee, Sunwoo

DOI: 10.1021/jo5003032

발행일: 2014-04-04

유형: Article

저널명: The Journal of Organic Chemistry

권: 79

호: 7

페이지: 3267 ~ 3271

언어: ENG

출판사: AMER CHEMICAL SOC

발행국가: 미국

분량: 5 페이지

ISSN: E 1520-6904
P 0022-3263