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Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells
- Hwang, Ji Sang;
- Lee, Seon A.;
- Hong, Seong Su;
- Han, Xiang Hua;
- Lee, Chul;
- ... Lee, Dongho;
- 외 5명
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76초록
Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC(50) values ranging from 9.6 mu M to 35.7 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
키워드
Dendrobium nobile; Orchidaceae; Phenanthrene; Bibenzyl; Nitric oxide inhibitor; SESQUITERPENE GLYCOSIDES; BIBENZYL DERIVATIVES; 2 STILBENOIDS; IN-VITRO; PICROTOXANE; COPACAMPHANE; MONILIFORME; CHRYSANTHUM; VIVO
- 제목
- Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells
- 저자
- Hwang, Ji Sang; Lee, Seon A.; Hong, Seong Su; Han, Xiang Hua; Lee, Chul; Kang, Shin Jung; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- 발행일
- 2010-06-15
- 유형
- Article
- 권
- 20
- 호
- 12
- 페이지
- 3785 ~ 3787
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 3 페이지
- ISSN
- E 1464-3405
P 0960-894X