상세 보기
Structure elucidation of a new triterpene fromInonotus obliquus
- Park, Sangmin;
- Shin, Hyeji;
- Park, Dawon;
- Kim, Hyunwoo;
- Byun, Youngjoo;
- ... Lee, Ki Yong
Citations
WEB OF SCIENCE
3Citations
SCOPUS
6초록
Ethyl acetate (EtOAc) fraction of theInonotus obliquus(Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity-guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5). Among them, Compounds2-4significantly reduced LPS-induced nitric oxide production to 4.5 +/- 0.8%, 47.4 +/- 4.4%, and 2.8 +/- 1.7%, respectively, at a concentration of 30 mu M.
키워드
anti-inflammatory; Inonotus obliquus; lanostane-type triterpene; INONOTUS-OBLIQUUS; CHEMICAL-CONSTITUENTS; MEDICINAL MUSHROOM; EXTRACT
- 제목
- Structure elucidation of a new triterpene fromInonotus obliquus
- 저자
- Park, Sangmin; Shin, Hyeji; Park, Dawon; Kim, Hyunwoo; Byun, Youngjoo; Lee, Ki Yong
- DOI
- 10.1002/mrc.5102
- 발행일
- 2021-04
- 유형
- Article
- 권
- 59
- 호
- 4
- 페이지
- 489 ~ 494