Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols

Irudayanathan, Francis Mariaraj; Kim, Jimin; Song, Kwang Ho; Lee, Sunwoo

doi:10.1002/ajoc.201600265

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Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols

Irudayanathan, Francis Mariaraj;
Kim, Jimin;
Song, Kwang Ho;
Lee, Sunwoo

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9

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초록

Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs2CO3 in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.

키워드

aldehydes; alkynyl carboxylic acid; decarboxylative coupling; ketones; propargyl alcohol; TRIFLUOROMETHYL KETONES; CATALYTIC ALKYNYLATION; CARBOXYLIC-ACIDS; TERMINAL ALKYNES; ALDEHYDES; EFFICIENT; AMINES; WATER; NANOPARTICLES; HETEROCYCLES

제목: Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols

저자: Irudayanathan, Francis Mariaraj; Kim, Jimin; Song, Kwang Ho; Lee, Sunwoo

DOI: 10.1002/ajoc.201600265

발행일: 2016-09

유형: Article

저널명: Asian Journal of Organic Chemistry

권: 5

호: 9

페이지: 1148 ~ 1154

언어: ENG

출판사: WILEY-V C H VERLAG GMBH

발행국가: 독일

분량: 7 페이지

ISSN: E 2193-5815
P 2193-5807