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Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder
- Lee, Moon-Soo;
- Yang, Jae-Won;
- Ko, Young-Hoon;
- Han, Changsu;
- Kim, Seung-Hyun;
- 외 3명
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37초록
We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.
키워드
attention deficit disorder with hyperactivity; dehydroepiandrosterone sulfate; methylphenidate; bupropion; DEHYDROEPIANDROSTERONE-SULFATE; DEFICIT/HYPERACTIVITY DISORDER; METABOLISM; RECEPTOR; BRAIN
- 제목
- Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder
- 저자
- Lee, Moon-Soo; Yang, Jae-Won; Ko, Young-Hoon; Han, Changsu; Kim, Seung-Hyun; Lee, Min-Soo; Joe, Sook-Haeng; Jung, In-Kwa
- 발행일
- 2008-06
- 유형
- Article
- 권
- 39
- 호
- 2
- 페이지
- 201 ~ 209