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A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils
- Han, Sewoon;
- Yan, Ji-Jing;
- Shin, Yoojin;
- Jeon, Jessie S.;
- Won, Jihee;
- ... Chung, Seok;
- 외 3명
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92초록
Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.
키워드
ENDOTHELIAL-CELLS; MICROFLUIDIC PLATFORM; LYMPHOCYTE MIGRATION; COLLAGEN GEL; TUMOR-CELLS; TRANSMIGRATION; INFLAMMATION; DIFFUSION; ANGIOGENESIS; METASTASIS
- 제목
- A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils
- 저자
- Han, Sewoon; Yan, Ji-Jing; Shin, Yoojin; Jeon, Jessie S.; Won, Jihee; Jeong, Hyo Eun; Kamm, Roger D.; Kim, Young-Joon; Chung, Seok
- 발행일
- 2012
- 유형
- Article
- 저널명
- Lab on a Chip
- 권
- 12
- 호
- 20
- 페이지
- 3861 ~ 3865