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초록
Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.
키워드
acetylcholinesterase; Alzheimer's disease; response surface methodology; Rhodiola sachalinensis; roseroot; LOW-DOSE REGIMEN; ALZHEIMERS-DISEASE; DOUBLE-BLIND; IMPAIRMENT; FATIGUE; STRESS; ROSEA; SHR-5
- 제목
- Application of Response Surface Methodology to Optimize the Extraction of Acetylcholinesterase Inhibitors from Rhodiola sachalinensis
- 저자
- Kim, Cho Rong; Kim, Jae Kyeom; Shin, Eui-Cheol; Choi, Soo Jung; Kwon, Yoon Kyung; Kim, Youn-Jung; Kim, Chang-Ju; Park, Gwi Gun; Park, Cheung-Seog; Shin, Dong-Hoon
- 발행일
- 2014-12
- 유형
- Article
- 권
- 57
- 호
- 6
- 페이지
- 807 ~ 811