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Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N-terminal cysteine for oligonucleotide-peptide conjugation
- Jang, Eui Kyoung;
- Koike, Yohei;
- Ide, Yuko;
- Tajima, Kunihiko;
- Kanaori, Kenji;
- ... Pack, Seung Pil
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9초록
In bioconjugation chemistry, achieving a target-specific reaction for a non-modified amino acid is challenging. Here, we report a novel nucleobase-involved native chemical ligation (NbCL) that allows a site-specific oligonucleotide-peptide conjugation via a new S-N acyl transfer reaction between an oxanine nucleobase and N-terminal cysteine.
키워드
NITRIC-OXIDE; DNA; TRIS(2-CARBOXYETHYL)PHOSPHINE; 2'-DEOXYOXANOSINE; STABILITY; MECHANISM; PROTEINS; DAMAGE
- 제목
- Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N-terminal cysteine for oligonucleotide-peptide conjugation
- 저자
- Jang, Eui Kyoung; Koike, Yohei; Ide, Yuko; Tajima, Kunihiko; Kanaori, Kenji; Pack, Seung Pil
- 발행일
- 2020-05-21
- 유형
- Article
- 권
- 56
- 호
- 41
- 페이지
- 5508 ~ 5511