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초록
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. This review introduces the basic concepts of What is polymorphism?, addresses a fundamental question of Why do polymorphs form?, and provides practical guidelines of How to prepare polymorphs? How to evaluate the relative thermodynamic stability between polymorphs?, and How to analyze polymorphs?. Moreover, case studies of pharmaceutically important polymorphs are provided. © 2014 Shenyang Pharmaceutical University.
키워드
Polymorph preparation; Polymorph screening; Polymorph selection; Polymorphs; acetylsalicylic acid; atorvastatin; axitinib; paracetamol; ritonavir; Article; crystallization; energy; kinetics; molecular biology; molecular dynamics; polymorphism; practice guideline; screening; thermodynamics
- 제목
- A practical guide to pharmaceutical polymorph screening & selection
- 저자
- Lee, E.H.
- 발행일
- 2014
- 유형
- Article
- 권
- 9
- 호
- 4
- 페이지
- 163 ~ 175
- 언어
- ENG
- 출판사
- Shenyang Pharmaceutical University
- 발행국가
- 대만
- 분량
- 13 페이지
- ISSN
- P 1818-0876