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Expression, purification, crystallization and preliminary X-ray analysis of the human NORE1 SARAH domain
- Kim, Hye Jin;
- Hwang, Eunha;
- Han, Young-Hyun;
- Choi, Saehae;
- Lee, Woo Cheol;
- ... Jeon, Young Ho;
- 외 3명
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1초록
NORE1 is an important tumour suppressor in human cancers that interacts with the pro-apoptotic protein kinase MST1/2 through SARAH domains. The SARAH domain (residues 366-413) of human NORE1 was expressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. The crystal diffracted to 2.7 angstrom resolution and belonged to space group P6(1)22, with unit-cell parameters a = b = 73.041, c = 66.092 angstrom, alpha = beta = 90, gamma = 120 degrees.
키워드
apoptosis; NORE1; Ras; tumour suppressors; TUMOR-SUPPRESSOR; IDENTIFICATION; PROTEINS; BINDING; PATHWAY
- 제목
- Expression, purification, crystallization and preliminary X-ray analysis of the human NORE1 SARAH domain
- 저자
- Kim, Hye Jin; Hwang, Eunha; Han, Young-Hyun; Choi, Saehae; Lee, Woo Cheol; Kim, Hye-Yeon; Jeon, Young Ho; Cheong, Chaejoon; Cheong, Hae-Kap
- 발행일
- 2012-07
- 유형
- Article
- 권
- 68
- 페이지
- 813 ~ 815
- 언어
- ENG
- 출판사
- INT UNION CRYSTALLOGRAPHY
- 발행국가
- 영국
- 분량
- 3 페이지
- ISSN
- E 2053-230X
P 2053-230X