상세 보기
Regioselective Synthesis of alpha-Functional Stilbenes via Precise Control of Rapid cis-trans Isomerization in Flow
- Lee, Hyune-Jea;
- Yonekura, Yuya;
- Kim, Nayoung;
- Yoshida, Jun-ichi;
- Kim, Heejin
Citations
WEB OF SCIENCE
11Citations
SCOPUS
14초록
The rapid cis-trans isomerization of alpha-anionic stilbene was regioselectively controlled by using flow microreactors, and its reaction with various electrophiles was conducted. The reaction time was precisely controlled within milliseconds to seconds at -50 degrees C to selectively give the cis- or trans-isomer in high yields. This synthetic method in flow was well-applied to synthesize precursors of commercial drug compound, (E)- and (Z)-tamoxifen with high regioselectivity and productivity.
키워드
ESTROGEN-RECEPTOR MODULATORS; POTENTIAL-ENERGY CURVES; FLASH CHEMISTRY; MULTIFUNCTIONAL MEDICINES; SERIAL MICROREACTIONS; ANTICANCER ACTIVITY; PLANT POLYPHENOLS; TAMOXIFEN; RESVERATROL; THERAPY
- 제목
- Regioselective Synthesis of alpha-Functional Stilbenes via Precise Control of Rapid cis-trans Isomerization in Flow
- 저자
- Lee, Hyune-Jea; Yonekura, Yuya; Kim, Nayoung; Yoshida, Jun-ichi; Kim, Heejin
- 발행일
- 2021-04-16
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 23
- 호
- 8
- 페이지
- 2904 ~ 2910