Peptide Assembly of Different Dimensions and Their Effect on Myoblast Proliferation

초록

Variations in the functionalitiesof materials of differentdimensionscontaining the same functional groups can be attributed to the structuralstability and morphology of the materials. The morphology of peptideassemblies can influence their interactions with biological systemsand ultimately modulate their bioactivity. Among reported Arg-Gly-Asp(RGD)-based supramolecular materials, two-dimensional (2-D) peptideassembly has been rarely studied. Herein, we report the fabricationof RGD-based supramolecular one-dimensional (1-D) and 2-D assembliesas peptide-based myoblast growth accelerators. The 2-D assembly wasmore effective in proliferating C2C12 cells than the 1-D assembly.These findings provide insights into the construction of optimal RGD-basedsupramolecular functional materials of different dimensions.

키워드