DSigDB: drug signatures database for gene set analysis

Yoo, Minjae; Shin, Jimin; Kim, Jihye; Ryall, Karen A.; Lee, Kyubum; Lee, Sunwon; Jeon, Minji; Kang, Jaewoo; Tan, Aik Choon

doi:10.1093/bioinformatics/btv313

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DSigDB: drug signatures database for gene set analysis

Yoo, Minjae;
Shin, Jimin;
Kim, Jihye;
Ryall, Karen A.;
Lee, Kyubum;
... Kang, Jaewoo;
외 3명

Citations

WEB OF SCIENCE

660

Citations

SCOPUS

686

초록

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.

키워드

SENSITIVITY; RESOURCE

제목: DSigDB: drug signatures database for gene set analysis

저자: Yoo, Minjae; Shin, Jimin; Kim, Jihye; Ryall, Karen A.; Lee, Kyubum; Lee, Sunwon; Jeon, Minji; Kang, Jaewoo; Tan, Aik Choon

DOI: 10.1093/bioinformatics/btv313

발행일: 2015-09-15

유형: Article

저널명: Bioinformatics

권: 31

호: 18

페이지: 3069 ~ 3071

언어: ENG

출판사: OXFORD UNIV PRESS

발행국가: 영국

분량: 3 페이지

ISSN: E 1367-4811
P 1367-4803