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초록
Asymmetric desymmetrization of the diallyl acetals of alkynal (1) by an enantioselective Pauson-Khand-type reaction catalyst was studied. The corresponding 5-oxabicyclo[3.3.0]octenones (2) were obtained as a mixture of diastereomers (2a and 2b), which were hydrolyzed to afford a single enantiomer (3), in high yields (up to 88%) as well as excellent enantioselectivities (up to 97%).
키워드
asymmetrric desymmetrization; atropisomeric ligands; enantioselective; Pauson-Khand reaction; rhodium(I); COMPLEX
- 제목
- Asymmetric Desymmetrization of the Diallyl Acetals of Alkynals by the Enantioselective Pauson-Khand-Type Reaction Catalysts
- 저자
- Kim, Dong Eun; Lee, Bo Hyung; Rajagopalasarma, Mudigonda; Genet, Jean-Pierre; Ratovelomanana-Vidal, Virginie; Jeong, Nakcheol
- 발행일
- 2008-11
- 유형
- Article
- 권
- 350
- 호
- 17
- 페이지
- 2695 ~ 2700