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Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
- Lee, Kyeong;
- Lee, Jee-Hyun;
- Boovanahalli, Shanthaveerappa K.;
- Choi, Yongseok;
- Choo, Soo-Jin;
- 외 5명
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19Citations
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19초록
We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against alpha-MSH induced melanin production in 816 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity. (C) 2010 Elsevier Masson SAS. All rights reserved.
키워드
(+)-Decursinol; (+)-Decursin; (+)-Decursinol angelate; Melanin inhibitors; PROTEIN-KINASE; ANGELICA-GIGAS; TYROSINASE; ACID; ROOT; DERIVATIVES; DECURSIN; AGENT; MOUSE
- 제목
- Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
- 저자
- Lee, Kyeong; Lee, Jee-Hyun; Boovanahalli, Shanthaveerappa K.; Choi, Yongseok; Choo, Soo-Jin; Yoo, Ick-dong; Kim, Dong Hee; Yun, Mi Young; Lee, Gye Won; Song, Gyu-Yong
- 발행일
- 2010-12
- 유형
- Article
- 권
- 45
- 호
- 12
- 페이지
- 5567 ~ 5575