Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Lee, Chul; Lee, Jin Woo; Jin, Qinghao; Jang, Dae Sik; Lee, Sung-Joon; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon

doi:10.1016/j.bmcl.2013.04.032

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Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Lee, Chul;
Lee, Jin Woo;
Jin, Qinghao;
Jang, Dae Sik;
Lee, Sung-Joon;
... Lee, Dongho;
외 4명

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43

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45

초록

Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as D-1, D-2 NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC50 value of 18.1 mu M. (C) 2013 Elsevier Ltd. All rights reserved.

키워드

Dalbergia odorifera; Leguminosae; Isoflavonoid; Nitric oxide; (2S)-Pinocembrin; FLAVONOIDS; ISOFLAVONOIDS

제목: Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

저자: Lee, Chul; Lee, Jin Woo; Jin, Qinghao; Jang, Dae Sik; Lee, Sung-Joon; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon

DOI: 10.1016/j.bmcl.2013.04.032

발행일: 2013-07-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 23

호: 14

페이지: 4263 ~ 4266

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: E 1464-3405
P 0960-894X