Small-molecule probe using dual signals to monitor leucine aminopeptidase activity

Yoon, Hey Young; Shim, So Hee; Baek, Luck Ju; Hong, Jong-In

doi:10.1016/j.bmcl.2011.02.068

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Small-molecule probe using dual signals to monitor leucine aminopeptidase activity

Yoon, Hey Young;
Shim, So Hee;
Baek, Luck Ju;
Hong, Jong-In

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24

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24

초록

Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity. (C) 2011 Elsevier Ltd. All rights reserved.

키워드

Leucine aminopeptidases; Probe; Dual signals; 2-Dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) unit; FLUORESCENCE DETECTION; DCDHF FLUOROPHORES; INHIBITORS; ASSAY

제목: Small-molecule probe using dual signals to monitor leucine aminopeptidase activity

저자: Yoon, Hey Young; Shim, So Hee; Baek, Luck Ju; Hong, Jong-In

DOI: 10.1016/j.bmcl.2011.02.068

발행일: 2011-04-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 21

호: 8

페이지: 2403 ~ 2405