Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Nguyen Tuan Hiep; Kwon, Jaeyoung; Kim, Dong-Woo; Hwang, Bang Yeon; Lee, Hak-Ju; Mar, Woongchon; Lee, Dongho

doi:10.1016/j.phytochem.2014.10.021

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Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Nguyen Tuan Hiep;
Kwon, Jaeyoung;
Kim, Dong-Woo;
Hwang, Bang Yeon;
Lee, Hak-Ju;
... Lee, Dongho;
외 1명

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WEB OF SCIENCE

43

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SCOPUS

45

초록

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

키워드

Cudrania tricuspidata; Moraceae; Isoflavones; Neuroprotection; Parkinson's disease; 6-OHDA; Human neuroblastoma SH-SY5Y; ROOT BARK; FLEMINGIA-PHILIPPINENSIS; PRENYLATED ISOFLAVONOIDS; ISOPRENYLATED XANTHONES; FLAVONOIDS; ERYTHRINA; CONSTITUENTS; COMPONENTS; CYTOTOXICITY; THONNINGII

제목: Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

저자: Nguyen Tuan Hiep; Kwon, Jaeyoung; Kim, Dong-Woo; Hwang, Bang Yeon; Lee, Hak-Ju; Mar, Woongchon; Lee, Dongho

DOI: 10.1016/j.phytochem.2014.10.021

발행일: 2015-03

유형: Article

저널명: Phytochemistry

권: 111

페이지: 141 ~ 148

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 8 페이지

ISSN: P 0031-9422