Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Lee, Haeun; Song, Woon Young; Kim, Minju; Lee, Min Wook; Kim, Soojeung; Park, Ye Song; Kwak, Kyungwon; Oh, Man Hwan; Kim, Hak Joong

doi:10.1021/acs.orglett.8b02789

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Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

Lee, Haeun;
Song, Woon Young;
Kim, Minju;
Lee, Min Wook;
Kim, Soojeung;
... Kwak, Kyungwon;
... Kim, Hak Joong;
외 2명

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WEB OF SCIENCE

17

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SCOPUS

19

초록

Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii.

키워드

siderophore; anguibactin; acinetobacter; drug-resistance; ANTIBACTERIAL ACTIVITY; VIBRIO-ANGUILLARUM; ESCHERICHIA-COLI; IRON ACQUISITION; ANTIBIOTICS; DELIVERY; ANALOGS

제목: Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

저자: Lee, Haeun; Song, Woon Young; Kim, Minju; Lee, Min Wook; Kim, Soojeung; Park, Ye Song; Kwak, Kyungwon; Oh, Man Hwan; Kim, Hak Joong

DOI: 10.1021/acs.orglett.8b02789

발행일: 2018-10-19

유형: Article

저널명: Organic Letters

권: 20

호: 20

페이지: 6476 ~ 6479