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Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity
- Lee, Sujin;
- Lee, Junghoon;
- Sim, Sang Jun;
- Cha, Misun
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0초록
The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by A beta. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca2+ flux pathways, should provide attractive targets for the future development of AD treatments.
키워드
ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; ACTIVATION; STRESS; CELLS; LIFE; VDAC
- 제목
- Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity
- 저자
- Lee, Sujin; Lee, Junghoon; Sim, Sang Jun; Cha, Misun
- 발행일
- 2014
- 유형
- Article
- 저널명
- RSC Advances
- 권
- 4
- 호
- 109
- 페이지
- 63681 ~ 63684
- 언어
- ENG
- 출판사
- ROYAL SOC CHEMISTRY
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 2046-2069
P 2046-2069