Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells

Kim, Jung Ah; Bae, Seong Ho; Choi, Young Joon; Kim, Kyung Hyun; Park, Sung Soo

doi:10.1016/j.bbrc.2012.04.051

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Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells

Kim, Jung Ah;
Bae, Seong Ho;
Choi, Young Joon;
Kim, Kyung Hyun;
Park, Sung Soo

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초록

F9 embryonic carcinoma (EC) cells undergo extra-embryonic endodermal (ExE) differentiation in response to retinoic acid (RA) treatment, which induces the expression of two isoforms (p96 and p67) of the adaptor protein, Disabled-2 (Dab2). In the current study, constitutive and ectopic expression of the p96 isoform induced ExE differentiation in F9 EC cells in the absence of RA treatment via the activation of GATA-4 by p96. During the RA-induced differentiation process, Dab2 expression is induced by the GATA factors in a coherent feed-forward loop; on the other hand, we showed that p96 regulates GATA-4 in a positive feed-back manner in this study. Our results indicate that p96 Dab2 plays a key role in the ExE differentiation process. (C) 2012 Elsevier Inc. All rights reserved.

키워드

Disabled-2 (Dab2); Extra-embryonic endoderm (ExE); Feed-back loop; GATA-4; RETINOIC ACID; EMBRYONAL CARCINOMA; VISCERAL ENDODERM; TRANSCRIPTION FACTOR; GENE-EXPRESSION; STEM-CELLS; BINDING; NETWORK; PROTEIN

제목: Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells

저자: Kim, Jung Ah; Bae, Seong Ho; Choi, Young Joon; Kim, Kyung Hyun; Park, Sung Soo

DOI: 10.1016/j.bbrc.2012.04.051

발행일: 2012-05-11

유형: Article

저널명: Biochemical and Biophysical Research Communications

권: 421

호: 3

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