Evaluation of safety and efficacy of adipose-derived stem cells in rat myocardial infarction model using hexadecyl-4-[I-124]iodobenzoate for cell tracking

초록

This study was aimed to evaluate the effect of I-124-labeling with hexadecyl-4-iodobenzoate (HIB) on gene expression related to cell cycle, DNA repair, transcription, proliferation and differentiation of adipose derived stem cells (ADSCs). [I-124]HIB showed high labeling efficiency with ADSCs (51.3 +/- 1.3%, 0.3-2.0 Bq/cell) and there is no morphological change of ADSCs. In the microarray analysis of gene expression pattern, differences were not observed between non-labeled and [I-124]HIB-labeled ADSCs. We demon-strated that I-124-labeling with HIB did not affect the biological properties of ADSCs. (C) 2015 Elsevier Ltd. All rights reserved.

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