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Developing imidazoles as CEST MRI pH sensors
- Yang, Xing;
- Song, Xiaolei;
- Banerjee, Sangeeta Ray;
- Li, Yuguo;
- Byun, Youngjoo;
- 외 4명
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58초록
A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N-H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright (C) 2016 John Wiley & Sons, Ltd.
키워드
chemical exchange saturation transfer; imidazole-4,5-dicarboxamides; molecular imaging; pH imaging; IN-VIVO; EXTRACELLULAR PH; CONTRAST AGENTS; EXCHANGE; IOPAMIDOL; PROTONS; ACID; COMPLEXES; GLUCOSE; SIGNAL
- 제목
- Developing imidazoles as CEST MRI pH sensors
- 저자
- Yang, Xing; Song, Xiaolei; Banerjee, Sangeeta Ray; Li, Yuguo; Byun, Youngjoo; Liu, Guanshu; Bhujwalla, Zaver M.; Pomper, Martin G.; McMahon, Michael T.
- 발행일
- 2016-07
- 유형
- Article
- 권
- 11
- 호
- 4
- 페이지
- 304 ~ 312
- 언어
- ENG
- 출판사
- WILEY-HINDAWI
- 발행국가
- 영국
- 분량
- 9 페이지
- ISSN
- E 1555-4317
P 1555-4309