Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii

Kim, Soojeung; Lee, Haeun; Song, Woon Young; Kim, Hak Joong

doi:10.1021/acs.orglett.0c00790

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Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii

Kim, Soojeung;
Lee, Haeun;
Song, Woon Young;
Kim, Hak Joong

Citations

WEB OF SCIENCE

16

Citations

SCOPUS

17

초록

The stereoselective synthesis of fimsbactin A, a siderophore of the human pathogen Acinetobacter baumannii, was established. Based on this synthetic route, various fimsbactin stereoisomeric analogues were generated and tested for their iron delivery activity for A. baumannii. This investigation revealed that the fimsbactin uptake machinery in this bacterium was indeed highly stereoselective in substrate recognition.

키워드

DEHYDRATIVE CYCLIZATION; ARTIFICIAL MEMBRANE; SIDEROPHORE; STEREOSPECIFICITY; IDENTIFICATION; MECHANISM

제목: Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii

저자: Kim, Soojeung; Lee, Haeun; Song, Woon Young; Kim, Hak Joong

DOI: 10.1021/acs.orglett.0c00790

발행일: 2020-04-03

유형: Article

저널명: Organic Letters

권: 22

호: 7

페이지: 2806 ~ 2810