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Bioactive constituents of the stem bark of Mitrephora glabra
- Li, C.;
- Lee, D.;
- Graf, T.N.;
- Phifer, S.S.;
- Nakanishi, Y.;
- 외 10명
Citations
SCOPUS
64초록
Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms. © 2009 American Chemical Society and American Society of Pharmacognosy.
키워드
aporphine derivative; liriodenine; Mitrephora glabra extract; plant extract; unclassified drug; antiinfective agent; antineoplastic agent; aporphine derivative; diterpene; liriodenine; polyacetylene derivative; Annonaceae; antimicrobial activity; article; bark; cancer cell culture; controlled study; cytotoxicity; drug isolation; heteronuclear multiple bond correlation; human; human cell; microorganism; Mitrephora glabra; nuclear magnetic resonance; plant stem; spectroscopy; Aspergillus niger; chemical structure; chemistry; drug effect; drug screening; female; Indonesia; isolation and purification; medicinal plant; microbiological examination; Micrococcus luteus; Mycobacterium; Saccharomyces cerevisiae; Mitrephora; Annonaceae; Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Aporphines; Aspergillus niger; Diterpenes; Drug Screening Assays, Antitumor; Female; Humans; Indonesia; Microbial Sensitivity Tests; Micrococcus luteus; Molecular Structure; Mycobacterium; Nuclear Magnetic Resonance, Biomolecular; Plant Bark; Plants, Medicinal; Polyacetylenes; Saccharomyces cerevisiae
- 제목
- Bioactive constituents of the stem bark of Mitrephora glabra
- 저자
- Li, C.; Lee, D.; Graf, T.N.; Phifer, S.S.; Nakanishi, Y.; Riswan, S.; Setyowati, F.M.; Saribi, A.M.; Soejarto, D.D.; Farnsworth, N.R.; Falkinham, III J.O.; Kroll, D.J.; Kinghorn, A.D.; Wani, M.C.; Oberlies, N.H.
- 발행일
- 2009
- 유형
- Article
- 권
- 72
- 호
- 11
- 페이지
- 1949 ~ 1953
- 언어
- ENG
- 발행국가
- 미국
- 분량
- 5 페이지
- ISSN
- E 1520-6025
P 0163-3864