Age of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty

Abstract

Purpose: Gonadotropin-releasing hormone agonist (GnRHa) is known for improvingfinal adult height in patients with central precocious puberty (CPP). This studyaimed to investigate the age of menarche and near adult height in girls with CPPwho had been treated with GnRHa. Methods: In this retrospective study, we reviewed the medical records of 71 Koreangirls with CPP who had started menarche or reached over 13 years of bone ageafter long-term GnRHa treatment. We estimated near adult height using the Bayley-Pinneau method and identified the age of menarche in girls with CPP. Results: Mean chronological and bone age at menarche were 11.9±0.7 and 12.8±0.4years, respectively. The period between menarche and the end of treatment was14.0±5.6 months. Posttreatment near adult height was 163.8±4.7 cm, which wassignificantly greater than pretreatment predicted adult height (158.7±4.1 cm). Conclusion: GnRHa treatment in girls with CPP could improve final adult height andmade the age of menarche close to that of the general population.