Effect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and SolifenacinEffect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and Solifenacin
- Other Titles
- Effect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and Solifenacin
- Authors
- 고경태; 양대열; 이원기; 김세웅; 문두건; 문기학; 박남철; 박종관; 손환철; 이성원; 현재석; 박광성
- Issue Date
- 2014
- Publisher
- 대한비뇨의학회
- Keywords
- Erectile dysfunction; Lower urinary tract symptoms; Overactive urinary bladder
- Citation
- Investigative and Clinical Urology, v.55, no.9, pp.608 - 614
- Indexed
- KCI
- Journal Title
- Investigative and Clinical Urology
- Volume
- 55
- Number
- 9
- Start Page
- 608
- End Page
- 614
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/100329
- ISSN
- 2466-0493
- Abstract
- Purpose: To evaluate how much the improvement of lower urinary tract symptoms(LUTS) affects sexual function and which storage symptoms or voiding symptoms havethe greatest effect on sexual function.
Materials and Methods: A total of 187 patients were enrolled in this study. Patientswere randomly assigned to receive either tamsulosin 0.2 mg (group A) or tamsulosin0.2 mg and solifenacin 5 mg (group B). At 4 weeks and 12 weeks, the LUTS and sexualfunction of the patients were evaluated by use of the International Index of ErectileFunction-5 (IIEF5), International Prostate Symptom Score (IPSS), Overactive BladderSymptom Score (OABSS) questionnaire, uroflowmetry, and bladder scan.
Results: Both groups A and B showed statistically significant improvements in IPSS,OABSS, and quality of life (QoL). Group A showed improved maximum flow rate, meanflow rate, and residual urine volume by time. Group B did not show an improvementin flow rate or residual urine volume but total voiding volume increased with time. TheIIEF5 score was not improved in either group. In group A, the IIEF5 score dropped from13.66±4.97 to 11.93±6.14 after 12 weeks (p=0.072). Group B showed a decline in theIIEF5 score from 13.19±5.91 to 12.45±6.38 (p=0.299). Although group B showed a relativelysmaller decrease in the IIEF5 score, the difference between the two groups wasnot significant (p=0.696).
Conclusions: Tamsulosin monotherapy and combination therapy with solifenacin didnot improve erectile function despite improvements in voiding symptoms and QoL. Theimprovement in storage symptoms did not affect erectile function.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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