Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kim, S. | - |
dc.contributor.author | Chung, J.-K. | - |
dc.contributor.author | Min, H.-S. | - |
dc.contributor.author | Kang, J.-H. | - |
dc.contributor.author | Park, D.J. | - |
dc.contributor.author | Jeong, J.M. | - |
dc.contributor.author | Lee, D.S. | - |
dc.contributor.author | Park, S.-H. | - |
dc.contributor.author | Cho, B.Y. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Lee, M.C. | - |
dc.date.accessioned | 2021-09-05T15:51:54Z | - |
dc.date.available | 2021-09-05T15:51:54Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100684 | - |
dc.description.abstract | Purpose: The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Materials and Methods: Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11). Results: Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. Conclusion: The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy. © 2014 Korean Society of Nuclear Medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | - |
dc.subject | glucose transporter 1 | - |
dc.subject | pendrin | - |
dc.subject | sodium iodide symporter | - |
dc.subject | thyroglobulin | - |
dc.subject | thyroid peroxidase | - |
dc.subject | thyrotropin receptor | - |
dc.subject | article | - |
dc.subject | clinical article | - |
dc.subject | controlled study | - |
dc.subject | densitometry | - |
dc.subject | gene expression | - |
dc.subject | histopathology | - |
dc.subject | human | - |
dc.subject | human tissue | - |
dc.subject | priority journal | - |
dc.subject | reverse transcription polymerase chain reaction | - |
dc.subject | thyroid carcinoma | - |
dc.subject | tumor differentiation | - |
dc.title | Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, S. | - |
dc.identifier.doi | 10.1007/s13139-013-0249-x | - |
dc.identifier.scopusid | 2-s2.0-84901306745 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Molecular Imaging, v.48, no.2, pp.91 - 97 | - |
dc.relation.isPartOf | Nuclear Medicine and Molecular Imaging | - |
dc.citation.title | Nuclear Medicine and Molecular Imaging | - |
dc.citation.volume | 48 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 97 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001882119 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | glucose transporter 1 | - |
dc.subject.keywordPlus | pendrin | - |
dc.subject.keywordPlus | sodium iodide symporter | - |
dc.subject.keywordPlus | thyroglobulin | - |
dc.subject.keywordPlus | thyroid peroxidase | - |
dc.subject.keywordPlus | thyrotropin receptor | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | densitometry | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human tissue | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | thyroid carcinoma | - |
dc.subject.keywordPlus | tumor differentiation | - |
dc.subject.keywordAuthor | Glucose transporter-1 | - |
dc.subject.keywordAuthor | Papillary thyroid cancer | - |
dc.subject.keywordAuthor | Pendrin | - |
dc.subject.keywordAuthor | Sodium/iodide symporter | - |
dc.subject.keywordAuthor | Thyroglobulin | - |
dc.subject.keywordAuthor | Thyroid peroxidase | - |
dc.subject.keywordAuthor | TSH receptor | - |
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