Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma
- Authors
- Kim, S.; Chung, J.-K.; Min, H.-S.; Kang, J.-H.; Park, D.J.; Jeong, J.M.; Lee, D.S.; Park, S.-H.; Cho, B.Y.; Lee, S.; Lee, M.C.
- Issue Date
- 2014
- Publisher
- Springer Verlag
- Keywords
- Glucose transporter-1; Papillary thyroid cancer; Pendrin; Sodium/iodide symporter; Thyroglobulin; Thyroid peroxidase; TSH receptor
- Citation
- Nuclear Medicine and Molecular Imaging, v.48, no.2, pp.91 - 97
- Indexed
- SCOPUS
KCI
- Journal Title
- Nuclear Medicine and Molecular Imaging
- Volume
- 48
- Number
- 2
- Start Page
- 91
- End Page
- 97
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/100684
- DOI
- 10.1007/s13139-013-0249-x
- ISSN
- 1869-3474
- Abstract
- Purpose: The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Materials and Methods: Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11). Results: Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. Conclusion: The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy. © 2014 Korean Society of Nuclear Medicine.
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