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A practical guide to pharmaceutical polymorph screening & selection
- Authors
- Lee, E.H.
- Issue Date
- 2014
- Publisher
- Shenyang Pharmaceutical University
- Keywords
- Polymorph preparation; Polymorph screening; Polymorph selection; Polymorphs
- Citation
- Asian Journal of Pharmaceutical Sciences, v.9, no.4, pp.163 - 175
- Indexed
- SCOPUS
- Journal Title
- Asian Journal of Pharmaceutical Sciences
- Volume
- 9
- Number
- 4
- Start Page
- 163
- End Page
- 175
- ISSN
- 1818-0876
- Abstract
- Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. This review introduces the basic concepts of What is polymorphism?, addresses a fundamental question of Why do polymorphs form?, and provides practical guidelines of How to prepare polymorphs? How to evaluate the relative thermodynamic stability between polymorphs?, and How to analyze polymorphs?. Moreover, case studies of pharmaceutically important polymorphs are provided. © 2014 Shenyang Pharmaceutical University.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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