기능성 소재 개발을 위한 돼지태반추출물의 경구 및 피부 동물모델 안정성 평가
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍양희 | - |
dc.contributor.author | 정은영 | - |
dc.contributor.author | 서형주 | - |
dc.date.accessioned | 2021-09-05T16:45:19Z | - |
dc.date.available | 2021-09-05T16:45:19Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2466-2046 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/100926 | - |
dc.description.abstract | Animal-derived placenta extract (PE) are available commercially and regularly used in various ointmentsand lotions for the purpose of improving skin properties. Although the effects of PE have been largelystudied, only a few scientific studies report the skin safety evaluations of PE derived from animals such aspig. The objective of this study was to evaluated the anti-aging potential and safety of collagen in subcriticalextract of porcine homogenate of placenta (SPE) for nutricosmetic and cosmeceutical ingredients. Theexperimental animals were divided into 6 groups, and were treated for 12 wks: positive control group (PO)treated with no-ultra violet (UV)B, negative control group (NO) treated with only UVB, experimental group1 (OSPE-1) low dosage oral application treated with SPE, experimental group 2 (OSPE-2) high dosageoral application treated with SPE, experimental group 3 (OSPE-1+FSPE-1) low dosage oral and topicalapplication treated with SPE, and experimental group 4 (OSPE-2+FSPE-2) high dosage oral and topicalapplication treated with SPE. The serum biochemical markers for liver, aspartate aminotransferase (AST),and alanine aminotransferase (ALT) were also not affected by the application of SPE at any groups. ButOSPE-2+FSPE-2 had significant (p<.05) decreased in lactate dehydrogenase (LDH) level compared thanNO. The skin safety was performed to evaluate of potential toxicity using the primary irritation test andskin sensitization test. The SPE did not show any adverse reactions such as erythema and edema onintact skin sites at primary irritation test, but on abraded sites, some experimental animals showed veryslight erythema. So, the SPE was classified as a practically non-irritating material based on the score 0.48of primary irritation index. The skin sensitization study was tested by the guinea pig maximization test(GPMT) and Freund’s complete adjuvant (FCA) with intradermal injection of SPE. The skin sensitization testshowed no skin sensitization. Based on this study, the potential for SPE a nutricosmetic and cosmeceuticalingredients were proven. | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.title | 기능성 소재 개발을 위한 돼지태반추출물의 경구 및 피부 동물모델 안정성 평가 | - |
dc.title.alternative | Oral and Topical Safety Evaluation of Porcine Placenta Extract for the Development of the Functional Ingredient Using Animal Models | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 서형주 | - |
dc.identifier.bibliographicCitation | 아시안뷰티화장품학술지, v.12, no.5, pp.733 - 743 | - |
dc.relation.isPartOf | 아시안뷰티화장품학술지 | - |
dc.citation.title | 아시안뷰티화장품학술지 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 733 | - |
dc.citation.endPage | 743 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001926640 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Porcine placenta extract | - |
dc.subject.keywordAuthor | Nutricosmetics | - |
dc.subject.keywordAuthor | Cosmeceutical | - |
dc.subject.keywordAuthor | Serum enzyme | - |
dc.subject.keywordAuthor | Skin safety | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.