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The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex
- Authors
- Yeo, Kwon Joo; Hwang, Eunha; Min, Kyong-Mi; Jee, Jun-Goo; Lee, Chung-Kyung; Hwang, Kwang Yeon; Jeon, Young Ho; Chang, Soo-Ik; Cheong, Hae-Kap
- Issue Date
- 2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.50, no.85, pp.12966 - 12969
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 50
- Number
- 85
- Start Page
- 12966
- End Page
- 12969
- ISSN
- 1359-7345
- Abstract
- The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.
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