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Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading
- Authors
- Lee, Yun Hak; Park, Nayoung; Park, Young Bin; Hwang, Yu Jeong; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.50, no.24, pp.3197 - 3200
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 50
- Number
- 24
- Start Page
- 3197
- End Page
- 3200
- ISSN
- 1359-7345
- Abstract
- Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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