Multiple GO-SELEX for efficient screening of flexible aptamers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen, Van-Thuan | - |
dc.contributor.author | Kwon, Young Seop | - |
dc.contributor.author | Kim, Jae Hoon | - |
dc.contributor.author | Gu, Man Bock | - |
dc.date.accessioned | 2021-09-05T17:02:46Z | - |
dc.date.available | 2021-09-05T17:02:46Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101060 | - |
dc.description.abstract | We describe a simple, high-speed, high-throughput aptamer screening for a group of small molecules using graphene oxide (simple Multi-GO-SELEX) without immobilizing targets. The affinities of ten different ssDNA aptamers successfully obtained for three pesticides were in the range of 10-100 nM. Besides a specific aptamer for each target, we found a couple of flexible multi-target aptamers, which can bind with 2 or 3 different molecules. These flexible aptamers developed for binding with a mixture of targets are not only significant for the rapid screening of a group of small molecules but also offer great promise for aptamer-based biosensor applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | PARKINSONS-DISEASE | - |
dc.subject | EXPOSURE | - |
dc.subject | PESTICIDES | - |
dc.subject | RISK | - |
dc.title | Multiple GO-SELEX for efficient screening of flexible aptamers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gu, Man Bock | - |
dc.identifier.doi | 10.1039/c4cc03953j | - |
dc.identifier.scopusid | 2-s2.0-84906273555 | - |
dc.identifier.wosid | 000340898400041 | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.50, no.72, pp.10513 - 10516 | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 50 | - |
dc.citation.number | 72 | - |
dc.citation.startPage | 10513 | - |
dc.citation.endPage | 10516 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | PESTICIDES | - |
dc.subject.keywordPlus | RISK | - |
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