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Multiple GO-SELEX for efficient screening of flexible aptamers

Authors
Nguyen, Van-ThuanKwon, Young SeopKim, Jae HoonGu, Man Bock
Issue Date
2014
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.50, no.72, pp.10513 - 10516
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
50
Number
72
Start Page
10513
End Page
10516
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101060
DOI
10.1039/c4cc03953j
ISSN
1359-7345
Abstract
We describe a simple, high-speed, high-throughput aptamer screening for a group of small molecules using graphene oxide (simple Multi-GO-SELEX) without immobilizing targets. The affinities of ten different ssDNA aptamers successfully obtained for three pesticides were in the range of 10-100 nM. Besides a specific aptamer for each target, we found a couple of flexible multi-target aptamers, which can bind with 2 or 3 different molecules. These flexible aptamers developed for binding with a mixture of targets are not only significant for the rapid screening of a group of small molecules but also offer great promise for aptamer-based biosensor applications.
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