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Effect of magnetic modulation of mitochondrial voltage-dependent anion channel 2 against beta-amyloid induced neurotoxicity

Authors
Lee, SujinLee, JunghoonSim, Sang JunCha, Misun
Issue Date
2014
Publisher
ROYAL SOC CHEMISTRY
Citation
RSC ADVANCES, v.4, no.109, pp.63681 - 63684
Indexed
SCIE
SCOPUS
Journal Title
RSC ADVANCES
Volume
4
Number
109
Start Page
63681
End Page
63684
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101094
DOI
10.1039/c4ra10755a
ISSN
2046-2069
Abstract
The magnetic capture of mitochondrial VDAC2 with bacterial magnetic particles (BMPs) conjugated VDAC2 antibody (BMPs-Ab) significantly decreased the expressed intracellular calcium levels and neurotoxicity induced by A beta. This magnetic modulation of mitochondrial VDAC, playing a key role in various Ca2+ flux pathways, should provide attractive targets for the future development of AD treatments.
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공과대학 (화공생명공학과)
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