Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet
DC Field | Value | Language |
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dc.contributor.author | Kim, Joo-Yeon | - |
dc.contributor.author | Lee, Mak-Soon | - |
dc.contributor.author | Jung, Sunyoon | - |
dc.contributor.author | Joo, Hyunjin | - |
dc.contributor.author | Kim, Chong-Tai | - |
dc.contributor.author | Kim, In-Hwan | - |
dc.contributor.author | Seo, Sangjin | - |
dc.contributor.author | Oh, Soojung | - |
dc.contributor.author | Kim, Yangha | - |
dc.date.accessioned | 2021-09-05T17:12:18Z | - |
dc.date.available | 2021-09-05T17:12:18Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101125 | - |
dc.description.abstract | Purpose: This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet. Methods: The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks. Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-alpha ctivated receptor (PPAR)-gamma, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to beta-oxidation or thermogenesis including PPAR-alpha, palmitoyltransferase-1 alpha, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-alpha ctivated protein kinase (AMPK) activity. In particular, PPAR-alpha, palmitoyltransferase-1 alpha, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not. Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehydrogenase in white adipose tissue. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.subject | MITOCHONDRIAL UNCOUPLING PROTEINS | - |
dc.subject | ADIPOCYTE DIFFERENTIATION | - |
dc.subject | PPAR-ALPHA | - |
dc.subject | EXPRESSION | - |
dc.subject | CAPSAICIN | - |
dc.subject | FORMULATIONS | - |
dc.subject | ACTIVATION | - |
dc.subject | MICE | - |
dc.subject | NUTRACEUTICALS | - |
dc.subject | ANTIOXIDANT | - |
dc.title | Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-Hwan | - |
dc.identifier.doi | 10.2147/IJN.S52414 | - |
dc.identifier.scopusid | 2-s2.0-84891783028 | - |
dc.identifier.wosid | 000329346000026 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp.301 - 310 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 301 | - |
dc.citation.endPage | 310 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MITOCHONDRIAL UNCOUPLING PROTEINS | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CAPSAICIN | - |
dc.subject.keywordPlus | FORMULATIONS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | NUTRACEUTICALS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordAuthor | oleoresin capsicum | - |
dc.subject.keywordAuthor | nanoemulsion | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | gene expression | - |
dc.subject.keywordAuthor | AMP-activated protein kinase | - |
dc.subject.keywordAuthor | rats | - |
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