A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T17:45:10Z | - |
dc.date.available | 2021-09-05T17:45:10Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0882-0139 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101224 | - |
dc.description.abstract | The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Delta 32) polymorphism is associated with multiple sclerosis (MS) susceptibility. Methods: Meta-analysis was conducted to determine the association between the CCR5-Delta 32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes. Results: In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Delta 32 allele polymorphism (OR = 1.102, 95% CI = 0.830-1.462, p = 0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Delta 32 allele and MS in Europeans (OR = 0.958, 95% CI = 0.811-1.132, p = 0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Delta 32 allele (OR = 1.234, 95% CI = 0.908-1.677, p = 0.178). In addition, no association was found between the CCR5-Delta 32 polymorphism and PP or SP-MS. Conclusions: Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Delta 32 polymorphism and MS risk in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | PROMOTER-308 A/G POLYMORPHISM | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | CCR5 DELETION MUTATION | - |
dc.subject | CLINICAL-COURSE | - |
dc.subject | CCR5-DELTA-32 POLYMORPHISM | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | ASSOCIATION | - |
dc.subject | BINDING | - |
dc.title | A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3109/08820139.2013.845204 | - |
dc.identifier.scopusid | 2-s2.0-84897978799 | - |
dc.identifier.wosid | 000334402500001 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGICAL INVESTIGATIONS, v.43, no.4, pp.299 - 311 | - |
dc.relation.isPartOf | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.title | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.volume | 43 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 299 | - |
dc.citation.endPage | 311 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | PROMOTER-308 A/G POLYMORPHISM | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | CCR5 DELETION MUTATION | - |
dc.subject.keywordPlus | CLINICAL-COURSE | - |
dc.subject.keywordPlus | CCR5-DELTA-32 POLYMORPHISM | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | CCR5-Delta 32 polymorphism | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | multiple sclerosis | - |
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