A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility
- Authors
- Song, Gwan Gyu; Lee, Young Ho
- Issue Date
- 2014
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- CCR5-Delta 32 polymorphism; meta-analysis; multiple sclerosis
- Citation
- IMMUNOLOGICAL INVESTIGATIONS, v.43, no.4, pp.299 - 311
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGICAL INVESTIGATIONS
- Volume
- 43
- Number
- 4
- Start Page
- 299
- End Page
- 311
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101224
- DOI
- 10.3109/08820139.2013.845204
- ISSN
- 0882-0139
- Abstract
- The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Delta 32) polymorphism is associated with multiple sclerosis (MS) susceptibility. Methods: Meta-analysis was conducted to determine the association between the CCR5-Delta 32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes. Results: In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Delta 32 allele polymorphism (OR = 1.102, 95% CI = 0.830-1.462, p = 0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Delta 32 allele and MS in Europeans (OR = 0.958, 95% CI = 0.811-1.132, p = 0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Delta 32 allele (OR = 1.234, 95% CI = 0.908-1.677, p = 0.178). In addition, no association was found between the CCR5-Delta 32 polymorphism and PP or SP-MS. Conclusions: Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Delta 32 polymorphism and MS risk in Europeans.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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