Uniform tricalcium phosphate beads with an open porous structure for tissue engineering
DC Field | Value | Language |
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dc.contributor.author | Ryu, Tae-Kyung | - |
dc.contributor.author | Oh, Myeong-Jin | - |
dc.contributor.author | Moon, Seung-Kwan | - |
dc.contributor.author | Paik, Dong-Hyun | - |
dc.contributor.author | Kim, Sung-Eun | - |
dc.contributor.author | Park, Jong-Hoon | - |
dc.contributor.author | Choi, Sung-Wook | - |
dc.date.accessioned | 2021-09-05T18:07:19Z | - |
dc.date.available | 2021-09-05T18:07:19Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-12-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101333 | - |
dc.description.abstract | Uniform tricalcium phosphate (TCP) porous beads with micro and macro pore sizes were fabricated using a simple fluidic device. For micro-porous TCP beads, an aqueous gelatin mixture containing TCP powder was introduced as the discontinuous phase into the fluidic device, where a toluene phase served as the continuous phase. The resulting aqueous TCP droplets were instantly frozen at -20 degrees C and freezedried, followed by calcination at 1200 degrees C. An oil-in-water-in-oil (O/W/O) emulsion templating method was employed to fabricate macro-porous TCP beads. An oil-in-water (O/W) emulsion was introduced into the fluidic device as the discontinuous phase with all other experimental conditions the same as for the micro-porous TCP beads. Uniform macro-porous TCP beads with a highly porous structure were finally obtained after freeze-drying and calcination. Large pore size and good interconnectivity of the macro-porous TCP beads were confirmed by scanning electron microscopy and porosimetry. In addition, penetration of host tissue into the macro-pores of the TCP beads was demonstrated by subcutaneously implanting the two types of porous TCP beads into mice and histologically analyzing stained sections at 1-4 weeks post implantation. The macro-porous TCP beads with a highly open porous structure could potentially be used as an injectable material for bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | CALCIUM-PHOSPHATE | - |
dc.subject | CEMENT | - |
dc.subject | FABRICATION | - |
dc.subject | IMPROVEMENT | - |
dc.subject | INJECTION | - |
dc.subject | SCAFFOLDS | - |
dc.title | Uniform tricalcium phosphate beads with an open porous structure for tissue engineering | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jong-Hoon | - |
dc.identifier.doi | 10.1016/j.colsurfb.2013.08.023 | - |
dc.identifier.scopusid | 2-s2.0-84883726895 | - |
dc.identifier.wosid | 000328593100052 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.112, pp.368 - 373 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 112 | - |
dc.citation.startPage | 368 | - |
dc.citation.endPage | 373 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | CALCIUM-PHOSPHATE | - |
dc.subject.keywordPlus | CEMENT | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | IMPROVEMENT | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordAuthor | Tricalcium phosphate | - |
dc.subject.keywordAuthor | Porous structure | - |
dc.subject.keywordAuthor | Tissue penetration | - |
dc.subject.keywordAuthor | Tissue engineering | - |
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