Comparison of clinical outcomes between first-generation and second-generation drug-eluting stents in type 2 diabetic patients
- Authors
- Jeong, Han Saem; Cho, Jae Young; Kim, Eun Ji; Yu, Cheol Woong; Ahn, Chul-Min; Park, Jae Hyoung; Hong, Soon Jun; Lim, Do-Sun
- Issue Date
- 12월-2013
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- diabetes; drug-eluting stents; major adverse cardiac event
- Citation
- CORONARY ARTERY DISEASE, v.24, no.8, pp.676 - 683
- Indexed
- SCIE
SCOPUS
- Journal Title
- CORONARY ARTERY DISEASE
- Volume
- 24
- Number
- 8
- Start Page
- 676
- End Page
- 683
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101402
- DOI
- 10.1097/MCA.0b013e3283650210
- ISSN
- 0954-6928
- Abstract
- BackgroundDrug-eluting stent (DES) implantation has significantly reduced the risk of restenosis and major adverse cardiac event (MACE) rates compared with bare-metal stents in type 2 diabetic patients. Differences in outcomes between the first-generation and second-generation DESs in diabetic patients, however, have yet to be evaluated.AimWe compared MACEs after second-generation DES implantation compared with those of first-generation stents in diabetic patients.Methods and resultsThis single-center prospective cohort study compared first-generation DES (n=654) and second-generation DES (n=339) implantation in type 2 diabetic patients by propensity score matching. The primary outcome was the occurrence of MACEs, defined as a composite of all-cause death, nonfatal myocardial infarction, and target vessel revascularization. The rate of MACEs was lower in the second-generation DES group after 2 years of follow-up (3.3 vs. 10.0%, P<0.001). Kaplan-Meier analysis showed higher MACE-free survival in diabetic patients in the second-generation DES group (log-rank P<0.001). In a Cox regression analysis, first-generation DES (hazard ratio=3.60, 95% confidence interval, 2.03-6.37, P<0.001) was an independent predictor for MACEs.ConclusionIn type 2 diabetic patients, second-generation DES implantation resulted in lower MACEs compared with first-generation DESs, primarily because of lower target lesion and vessel revascularization rates.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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